Our research is focused on the structure, dynamics, molecular interactions and biological function of peptides and proteins, studied by the synergistic combination of spectroscopic and simulative methods. We are currently studying and developing different peptide classes with potential therapeutic applications, such as host defense peptides, promising molecules to fight drug-resistant bacteria, or peptides and peptidomimetics designed to interfere with protein-protein interactions involved in cancer and several congenital disorders. In this context, we also study the structural, dynamical and functional effects of pathogenic mutations linked to these diseases.